For example, cancer-associated fibroblasts (CAFs) can secrete a series of cytokines to suppress the immune response, VEGF to regulate the tumor vascular network, TGF-β to inhibit DC maturation and promote Treg differentiation etc., and hinder the infiltration of drugs and immune cells through the extracellular matrix (105, 106). The gene discussed is TGFB1; the disease is neoplasm.