TAC1 and colorectal carcinoma: In addition, Tac1 mRNA in mice colon was increased after cisplatin injection (M vs. MC = 1.41 vs. 2.84, Figure 2G, p < 0.01), and the combination of THD and C. butyricum could notably downregulate the relative expression of Tac1 mRNA in CRC mouse with cisplatin chemotherapy (1.09, p < 0.01).