Cisplatin chemotherapy in MC group would further upregulate the relative expression of Il6 (11.92, p < 0.01), Il1b (9.36, p < 0.01) and Tnf (7.28, p < 0.05) than M group, whereas THD (p < 0.01), C. butyricum (p < 0.01), and the combination of THD and C. butyricum (p < 0.01) inhibited the up-regulated levels of these inflammatory cytokines in CRC mice with cisplatin chemotherapy. Here, TNF is linked to colorectal carcinoma.