In SLE patients, neutrophils exhibit phenotypic and functional abnormalities such as failure of C1q/calreticulin and CD91-mediated apoptotic pathways to clear phagocytic defects, increased aggregation of abnormal oxidative activity, and increased numbers of circulating low-density granulocytes (LDGS) (68). Here, LRP1 is linked to systemic lupus erythematosus.