CD4 and systemic lupus erythematosus: In contrast, in the SLE dataset, LCK, PLCG1, and RASGRP1 were positively correlated with activated CD8 T cells, effector memory CD4 T cells, central memory CD4 T cells, central memory CD8 T cells and effector memory CD8 T cells (P < 0.01), and negatively correlated with neutrophils (P < 0.05) (Figure 11C).