There is extensive evidence that some HLA-DRB1 alleles, including HLA-DRB1*01, HLA-DRB1*04, HLA-DRB1*09, HLA-DRB1*10, and HLA-DRB1*14 implicated with RA susceptibility in different populations (7–11). The gene discussed is HLA-DRB1; the disease is rheumatoid arthritis.