1、In MRE11A low CD4+ T cells, leaked mtDNA triggers NLRP3 and AIM2 inflammasomes assembly, inducing GSDM-dependent pyroptosis.2、Up-regulating the expression of MRE11A in RA CD4+ T cells can reduce the generation of pyroptosis and slow down the progression of synovitis. The gene discussed is AIM2; the disease is synovitis.