1、C1q and PTX3 act synergistically to induce GSDMD-dependent pyroptosis in CD14+ monocytes, and the released IL-6 can further promotes pyroptosis in normal and RA monocytes.2、TNF-α can induce pyroptosis through caspase-3-GSDME pathway in RA-monocytes/macrophages.3、Pol β deficiency promote LPS plus ATP-mediated pyroptosis in RA-macrophage by activating the cGAS-STING-NF-κB signaling pathway.4、MiR-33 promotes RA-macrophage pyroptosis by positively regulating NLRP3. The gene discussed is STING1; the disease is hyperinsulinemic hypoglycemia, familial, 4.