1、In MRE11A low CD4+ T cells, leaked mtDNA triggers NLRP3 and AIM2 inflammasomes assembly, inducing GSDM-dependent pyroptosis.2、Up-regulating the expression of MRE11A in RA CD4+ T cells can reduce the generation of pyroptosis and slow down the progression of synovitis. Here, CD4 is linked to synovitis.