In hypoxic environment, p-STAT3 interacts with PD-L1 physically to enhance the transcription of GSDMC. At the same time, under the treatment of TNF-α, activated caspase-8 cleaves GSDMC in MDA-MB-231 breast cancer cells to induce GSDMC-mediated pyroptosis (58). This evidence concerns the gene GSDMC and breast carcinoma.