1、TNF-α plus hypoxia induce GSDME-mediated pyroptosis in FLS.2、Hypoxia trigger GSDMD-mediated pyroptosis through ROS-GRK2-HIF-1α-NLRP3-caspase-1-GSDMD signal axis.3、SFRP1 can negatively regulate NLRP3-mediated pyroptosis through Wnt/b-catenin and Notch signaling pathways in RA-FLS.4、LPS can induce FLS pyroptosis through NLRP-3-caspase-1-GSDMD and caspase-3-GSDME signaling pathways.5、Hsa_circ_0044235 inhibit NLRP3-mediated FLS pyroptosis through the miR-135b-5p-SIRT1 signaling axis. Here, GSDME is linked to rheumatoid arthritis.