1、Extracellular acidosis trigger chondrocyte pyroptosis and pyroptosis related protein such as ASC, NLRP3 and caspase-1 are significantly increased in RA-chondrocyte.2、MiR-144-3p-activated chondrocyte pyroptosis is regulated by the PTEN/PINK1/Parkin signaling axis. Here, NLRP3 is linked to rheumatoid arthritis.