We screened the expression of a total of 404 different genes related to inherited cardiovascular disease in the proband (III-4) and her sister (III-2),27 and we identified a heterozygous stop-gain variant (c.T1890G p.Y630X) in procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (PLOD3), which encodes LH3 and was detected only in the proband (Figures 2D and 2E). This evidence concerns the gene PLOD3 and cardiovascular disorder.