HIV negative, No no immunodeficiency profile completed, ANA 1:160, anti-SSA/Ro antibody titer > 8 UI/mL, anti-DNA negative, anti-phospholipid antibodies negative, ANCA negative. Anti-MOG negative, anti-thyroid antibodies negative, CSF antiparaneoplastic panel (NMDA, anti-AMPA and anti-VGKC) negative, Serum antiparaneoplastic panel (anti-Yo, -Ri, -GAD, -Hu, -CV and -Tr antibodies) negative. The gene discussed is CALR; the disease is immune system disorder.