Vitamin B12 level 245 pg./m, CRP normal, TSH normal, hemoglobin A1C normal, aldolase normal, methylmalonic acid normal, antinuclear antibody normal, Jo-1 normal, SS-A/Ro negative, SS-B/La negative, ribonucleoprotein normal, scleroderma negative, DsDNA negative, anti-ribosomal, chromatin normal, centromere B antibodies negative, C3 & C4 compliments normal. The gene discussed is CALR; the disease is scleroderma.