TLR2 and allergic disease: Polymorphisms in TLR2 and TLR4 genes were discussed to influence the onset of allergic diseases, although a case-control study including atopic children with asthma, children suffering from non-atopic asthma and children with AR did not find a significant association between these two TLRs and allergic disorders, but an association with the disease ́s severity was suggested (Hussein et al., 2012).