The PI3K-Akt signaling pathway has an important role in the pathogenesis of heart disease, not only regulating the survival and function of cardiomyocytes, but also influencing the proliferation, migration, and apoptosis of vascular smooth muscle cells through the regulation of the pathogenesis and development of CHD (Magaye et al., 2021; Qin et al., 2021; Sun G. et al., 2021). This evidence concerns the gene AKT1 and heart disorder.