In particular, miRNAs could regulate the expression of urate transporter genes, e.g., miR-34a regulates the mRNA of the solute carrier family 22 member 12 (SLC22A12) gene to ultimately repress the uric acid transporter 1 (URAT1) expression in the animal model of hyperuricemia (26). The gene discussed is SLC2A9; the disease is hyperuricemia.