More importantly, supraphysiological concentrations of 25(OH)D3 resulting from artificial vitamin D supplementation can act as a VDR agonist (186), inhibiting Hedgehog (Hh) pathway, reducing the production of hepatitis C virus (HCV) largely, blocking an important predisposing factor for liver cirrhosis (187). The gene discussed is VDR; the disease is cirrhosis of liver.