Notably, among the 46 significant SNPs that were shared between MDD and severe COVID-19 (Supplementary Table S2), the most significant one was rs2234358 (Pmeta = 2.46 × 10−11) located within FYCO1:CXCR6, which is also shared by MDD and hospitalized COVID-19 (sentinel SNP [the most significant SNP]: rs17689471, Pmeta = 1.48 × 10−12). Here, CXCR6 is linked to COVID-19.