By analyzing the correlation between serum MBD3 expression in CPP patients and clinical baseline characteristics using bivariate correlation analysis, we disclosed that serum MBD3 expression in CPP patients was positively associated with basal LH (r = 0.229, P = 0.016), peak LH (r = 0.299, P = 0.002), basal FSH (r = 0.252, P = 0.008), and the size of right ovary (r = 0.226, P = 0.018) and left ovary (r = 0.208, P = 0.030) (Table 2). The gene discussed is BRD2; the disease is central precocious puberty.