To investigate potential genetic determinants of statin treatment effect heterogeneity, we studied interactive effects of the rs17238484 variant and 256 SNPs associated with T2D, LDL, high–density lipoprotein (HDL) cholesterol, and the coronary artery disease (CAD) gene which plays a central role in obesity and insulin sensitivity (Kozak and Anunciado-Koza, 2009; Rodrigues et al., 2013). The gene discussed is INS; the disease is coronary artery disorder.