In B. malayi infections, p46+ NK cells with an activated/memory phenotype and residual eosinophilia are implicated in the innate immune resistance to chronic infection in RAG2−/− mice (Pionnier et al., 2022), whereas in Litomosoides infections, CD45−/TCRβ−/CD90.2+/Sca-1+/IL-33R+/GATA-3+ type-2 innate lymphoid cells (ILC2) are required for innate immune resistance to microfilarial blood infections (Reichwald et al., 2022). This evidence concerns the gene RAG2 and Increased total eosinophil count.