However, experimental infections with B. malayi, L. sigmodontis, and O. ochengi in lymphopenic mouse strains (SCID/RAG2−/−) with additive γc gene ablations have illustrated bolstered chronic susceptibility (Layland et al., 2015; Pionnier et al., 2022), whilst in L. loa subcutaneous infections, only combination of lymphopenia and γc deficiency is sufficient to allow permissiveness to adult infections (Pionnier et al., 2019). Here, RAG2 is linked to lymphopenia.