GC and lymphopenia: However, experimental infections with B. malayi, L. sigmodontis, and O. ochengi in lymphopenic mouse strains (SCID/RAG2−/−) with additive γc gene ablations have illustrated bolstered chronic susceptibility (Layland et al., 2015; Pionnier et al., 2022), whilst in L. loa subcutaneous infections, only combination of lymphopenia and γc deficiency is sufficient to allow permissiveness to adult infections (Pionnier et al., 2019).