Interestingly, we detected a loss of methylation and an increase in accessibility after HIV-1 infection in memory CD8 T cells at the intron of DGKH (Figure 4C), a gene previously reported to exhibit differential methylation between elite controllers (individuals able to maintain undetectable viral loads for at least 12 months without antiretroviral therapy) and individuals receiving antiretroviral therapy (Frias et al., 2021). This evidence concerns the gene CD8A and HIV-1 infection.