To address whether IFITM proteins act as a barrier to SARS-CoV-2 infection in primary human nasal epithelia, we tested the impact of the antifungal Amphotericin B on infection with recombinant WA1 (WA1 Spike), WA1 (Delta Spike), and WA1 (BA.1 Spike). The gene discussed is CFB; the disease is infection.