APOE and dementia: The majority of differences across signals mapped to rs429358 (MAFAFR:AFR=0.22,MAFAMR=0.12,MAFEUR=0.14), the coding variant tag for APOE-e4 associated with a 30% lower risk of dementia in the AFR compared to the EUR population (48); there was no heterogeneity in the effect estimate between the AMR and the EUR population.