Furthermore, because breast carcinoma can rapidly expand to the brain lung, bone, and liver, which is deadly, the function of TGF-β in breast carcinoma metastasis should be highlighted (Medeiros and Allan 2019, Sofi et al., 2022, Sofi et al., 2023, Mir et al., 2020). The gene discussed is TGFB1; the disease is breast carcinoma.