Multiple premature symptoms develop due to an insertion mutation in the α-Klotho gene, such as skin atrophy, motor neuron degeneration, organ atrophy, osteopenia, sarcopenia, atherosclerosis, thymic atrophy, vascular calcification, hypoglycemia, gonadal dysplasia, infertility, hyperphosphatemia, hearing impairment, and pulmonary emphysema, and overall life expectancy shortens, with these symptoms developing due to aging [1]. This evidence concerns the gene KL and atherosclerosis.