TNF and COVID-19: While many cytokines were significantly elevated in MIS-C, (Granzyme B, INF- γ, IL-4, IL-7, IP-10, MIP-1α, TNF-α, sCD137) Figure 5, Supplementary Figure S3), consistent in part with prior immunoprofiling reports (32, 33), these cytokines were unable to distinguish between WHO severity cohorts of pediatric COVID-19.