Several reports have shown that a meta‐temporal region,42 or a temporoparietal (including posterior cingulate) AD‐signature region43, 44 outperforms the Braak staging for the early detection of cortical tau, for establishing the differential diagnosis of AD versus non‐AD neurodegenerative conditions,45 as well as for capturing longitudinal changes in cortical tau signal. The gene discussed is MAPT; the disease is Alzheimer disease.