The most prevalent gene categories associated with DCM are sarcomeric genes (TTN, NYH7, ACTC1, TNNT2, TPM1), the LMNA gene involved in nuclear envelope defects (laminopathies), genes encoding proteins comprising the cytoskeleton (such as FLNA, DMD, DES), and genes encoding desmosomes, which have also been reported in Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC). This evidence concerns the gene DES and familial dilated cardiomyopathy.