ALPK3 and familial dilated cardiomyopathy: However, due to expanded testing, new data concerning genes with previously limited data are also accumulating, increasing our knowledge of their impact on CVD heritability, such as the ALPK3 gene recently defined by the Clingen effort as a gene with strong disease association, while more recently data concerning FHOD3 also suggest its role as a causal gene for HCM and eventually DCM (46, 63).