PCSK9 and familial hyperaldosteronism: FH is an autosomal dominant disorder most commonly associated with variants in the LDL receptor (LDLR) gene, although variants in the apolipoprotein B (APOB) gene, primarily in the LDLR-binding region of the protein, or gain-of-function variants in protein convertase subtilisin/kexin 9 (PCSK9) have also been detected.