Meanwhile, our findings indicate a clear correlation between the gene expression patterns of Ptgs2, Hmox1, and Slc7a11 and the changes in the Ferroptosis pathway Z-score during sepsis-induced heart injury (Figures 2D, 5C), indicating the specific relationship among Ptgs2, Hmox1, Slc7a11, and ferroptosis in sepsis-induced heart injury. The gene discussed is PTGS2; the disease is Sepsis.