FGF21 and obesity due to melanocortin 4 receptor deficiency: In this study, we have confirmed that the risk factors of diabetes complicated with HP are closely related to body shape, the frequency of chronic complications of diabetes such as HP is high, and an increased prevalence of abdominal obesity was observed with higher serum level of FGF21, in other words, FGF21 resistance occurs in obesity patients in T2DM with HP.