Serum FGF21 levels were significantly higher in T2DM patients with HP than those without [534.9 (322.6–722.2) vs. 220.65 (142.8–347.55) pg/ml, p < 0.001], and levels in both of these two groups were significantly increased compared with that of healthy control [123.92 (67.23–219.32) pg/ml, all p < 0.001]. Here, FGF21 is linked to type 2 diabetes mellitus.