FGF21, waistline, age, HbA1c, and eGFR are independent risk factors for T2DM complicated with HP, suggesting that elderly individuals with abdominal obesity should pay more attention to weight control, not only blood-sugar control, to prevent the occurrence of HP, thus reduced the risk of cardiovascular death in patients with T2DM at high risk for cardiovascular events. This evidence concerns the gene FGF21 and type 2 diabetes mellitus.