It is reported that the proportion of the G allele in PNPLA3 and the T allele in TM6SF2 in lean NAFLD patients is significantly higher than that in non-lean NAFLD patients, and the mutations of these two alleles are highly related to the disorder of glucose and lipid metabolism (111). The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatotic liver disease.