Aurora kinase C (AURKC) is the only definite cause of macrozoospermia (7); dysfunction of dpy-19 like 2 (DPY19L2) (8), chromosome 7 open reading frame 61 (C7orf61) (9), c2 calcium-dependent domain containing 6 (C2CD6) (9), gametogenetin (GGN) (9), coiled-coil domain containing 62 (CCDC62) (10), calicin (CCIN) (11), protein interacting with PRKCA 1 (PICK1) (12), spermatogenesis associated 16 (SPATA16) (13) and zona pellucida binding protein 1 (ZPBP1) (14) are associated with globozoospermia. The gene discussed is AURKC; the disease is spermatogenic failure 5.