ERBB2 and lymphangioma: For example, previous evidence has demonstrated that HER2 could upregulate the expression of chemokine receptor-4 (CXCR4), thereby promoting LM via the CXCL12/CXCR4 signaling pathway (28), and overexpression of fibroblast growth factor homologous factor could induce the formation and occurrence of LM in triple-negative BC (29).