For example, previous evidence has demonstrated that HER2 could upregulate the expression of chemokine receptor-4 (CXCR4), thereby promoting LM via the CXCL12/CXCR4 signaling pathway (28), and overexpression of fibroblast growth factor homologous factor could induce the formation and occurrence of LM in triple-negative BC (29). This evidence concerns the gene CXCL12 and lymphangioma.