In lncRNA expression analysis conducted on EBC samples derived from patients with NSCLC and healthy controls, the expression profiles of MALAT1, HOTAIR, PVT1, NEAT1, ANRIL, and SPRY4-IT1 have been found, and an association between these expression profiles and molecular pathogenesis of LC has been established. This evidence concerns the gene SPRY4 and non-small cell lung carcinoma.