CECR2 and neural tube defect: CECR2 has roles in neurulation, and the loss of CECR2 in mice can induce exencephaly (a perinatal-lethal cranial NTD), or lead to implantation failure or neonates with open eyelids (Banting et al., 2005; Thompson et al., 2012; Leduc et al., 2017).