In addition to the statistically significant indicators in Tables 1–3, including gender, years of education, history of hypertension, and levels of HMGB1, UA, and HbAlc, as well as the presence of CMBs and LI, the effects of age, history of cerebral infarction, history of cerebral hemorrhage, and other imaging markers of CSVD: WMH and EVPS, on cognitive function should also be considered. This evidence concerns the gene HMGB1 and Hypertension.