The presence or absence of CMBs was used as the dependent variable, and age, gender, years of education, CSVD imaging markers, patients’ past history, and biochemical data were used as independent variables in univariate Logistic regression analysis, which showed that age, history of cerebral hemorrhage, history of heart disease, history of hypertension, history of smoking, history of drinking, HMGB1, UA, ALT, and AST were risk factors for CMBs (P < 0.05). The gene discussed is HMGB1; the disease is hypertensive disorder.