Since Siglec‐G is a negative regulator of BCR signaling in normal CD5+ B1a cells (Hoffmann et al, 2007) and since BCR signaling is crucial for CLL development and maintenance (Burger & Chiorazzi, 2013; Schmid et al, 2022), these results were not unexpected. Here, CD5 is linked to B-cell chronic lymphocytic leukemia.