Murine CD5+ B1a cells have some similar characteristics to human CD5+ CLL cells, for example, by expressing a restricted IgVH repertoire with a preferred usage of VH11 and VH12 families, including specificities for autoantigens and microbial antigens (Herve et al, 2005; Baumgarth, 2011). The gene discussed is CD5; the disease is B-cell chronic lymphocytic leukemia.