The dependence of CLL on BCR signaling is not due to BCR‐activating mutations in crucial signaling molecules as shown for diffuse B cell lymphoma (DLBCL) (Schmitz et al, 2018), but due to the ability of some CLL BCRs to cluster by binding to each other and in this way autonomously activating BCR signaling (Duhren‐von Minden et al, 2012; Minici et al, 2017). This evidence concerns the gene BCR and diffuse large B-cell lymphoma.