CRP and Stroke: Other markers of systemic inflammation, including inflammatory cytokines (e.g. Interleukin-1, C-reactive protein), are associated with fatigue.42 Excessive cytokine production and immune dysregulation decrease several neurotransmitters, which could play a role.43 Following stroke, microglia (the resident immune cells of the brain) become overactive, driving chronic neuroinflammation.44 Links between microglial activation and post-stroke fatigue are yet to be directly investigated.