As direct regulators of cytokines, NLRs play a connecting role in the cellular response to stress stimulation and participate in the malignant transformation and evolution of tumor cells.[6] We observed that NLRP11 was the most significantly differentially expressed gene among NLRs in early‐stage LUAD and adjacent tissues, and its high expression predicted a poor prognosis, suggesting that NLRP11 may be involved in the occurrence and development of LUAD. Here, NLRP11 is linked to neoplasm.