Principal considerations including cancer cell stemness, cell adhesion, cell proliferation, and DNA repair could contribute to drug chemoresistance during tumor treatment.[17] The chemoresistance‐related markers, such as E‐cadherin, hypoxia, and cancer cell stemness were analyzed using immunofluorescence and qPCR further to explore the mechanism of drug resistance in MCF‐7 cells. The gene discussed is CDH1; the disease is cancer.