Tumor cells cultured on ECM may trigger CDCA8 and promote drug resistance.[36] TOPO1 and TOPO2 are important regulators of DNA replication and are overexpressed in cancer cells.[37] The MGMT gene can also encode the typical protein of DNA damage repair to discard alkylating components for antidrug resistance of chemotherapy.[38] A higher MGMT expression was exhibited in the nonmodified and PDA‐modified groups to achieve efficient drug resistance. The gene discussed is MGMT; the disease is cancer.