TTP is a specific type of thrombocytopenia which constitutes a medical emergency, and a delay in implementing appropriate therapy is associated with substantial morbidity and mortality [6, 17].To the best of our knowledge, this is the fourth reported case of TTP associated with hepatitis E, and the first case involving a severely affected male patient who was diagnosed with TTP using an ADAMTS13 test in EICU. This evidence concerns the gene ADAMTS13 and thrombotic thrombocytopenic purpura.