The α‐diversity evaluation showed no significant differences among the four groups with regard to the 7 indices examined, such as the Chao1 index (P > 0.05), suggesting that GPR35‐mediated KA sensing exhibited no obvious effect on the α‐diversity of the gut microbiome during the progression of colitis (Fig. 2C, Fig. S2). The gene discussed is GPR35; the disease is colitis.