Among the strengths of this study are a most comprehensive analysis of both the Se and TH status of a set of high-quality samples from CFS patients and their potential interrelationship, providing a consistent picture and a novel plausible pathway for SELENOP-aAb inducing local selenoprotein deficiency, oxidative stress and hypothyroidism in Se-sensitive tissues. Here, SELENOS is linked to hyperinsulinemic hypoglycemia, familial, 4.