Recently, SerpinA3N/SerpinA3 has been found to be significantly upregulated in neurological diseases, such as traumatic brain injury, Alzheimer's disease, ischemic stroke, hippocampal stab injury, glioma, hypothalamus inflammation, and plays an important role in the development of the disease [25–30]. The gene discussed is SERPINA3; the disease is early-onset autosomal dominant Alzheimer disease.