SERPINA3 and early-onset autosomal dominant Alzheimer disease: Relatively consistent, the expression of SerpinA3N or SerpinA3 was upregulated in aging mice and mice with pineal inflammation, diabetes, traumatic brain injury, Alzheimer's disease, aneurysmal subarachnoid hemorrhage, glioma, colon cancer and other diseases [21, 26–32, 60–62].