TP53 and B-cell chronic lymphocytic leukemia: Frontline Acala ± Obi demonstrated similar 4-year PFS for both patients with TP53-aberrant CLL compared with all unselected patients; 87.0% [AO] and 77.9% [A] overall, and 74.8% [AO] and 76.2% [A] for TP53 aberrancy [6], and was shown to be as efficacious for TP53 aberrant CLL in the R/R setting (ELEVATE RR) [59].