The important role of the stromal cell-derived factor-1/chemokine receptor CXCR4 (SDF-1/CXCR4) axis in fibroblast recruitment and other pro-inflammatory and pro-fibrotic activities has been reported, and CXCR4 inhibition is a promising therapeutic target for PF [71–73]. This evidence concerns the gene CXCR4 and pemphigus foliaceus.