CFH and infection: Contrary to those up-regulated genes, we found down-regulated genes directly related with the activation of immune system processes: serpinb1, which is suggested to be activated upon an infection [115]; the tyrobp gene, which participates in the activation of immune cells involved in inflammatory reactions and as a component of NK cells with anti-viral functions [116]; and the cfh gene, which regulates the alternative pathway of the complement system [117].