The results revealed that SMI-4a had the inhibitory effect on AIM2 inflammasome and NLRC4 inflammasome, trigged by poly (dA:dT) transfection or Salmonella infection (Fig. 3g, h, Additional file 1: Fig. S3g), resulting in a decrease in IL-1β production. Here, AIM2 is linked to Salmonella Infections.