Of note, cancer-relevant proteins, such as fms-like tyrosine kinase 3 (FLT3) and heat shock protein 90 α (family class A member 1, HSP90AA1, HSP90α), were differentially secreted upon ADAM10 KO, indicating that they may represent candidates mediating the pro-tumorigenic function of ADAM10 in leukemia (Figs. 5D, E, S13 and Table S9). This evidence concerns the gene ADAM10 and leukemia.