Among interesting candidates to mediate leukemia crosstalk with the microenvironment is the metalloproteinase ADAM10 (A disintegrin and metalloproteinase domain-containing protein 10), which mediates ectodomain shedding of transmembrane proteins to regulate basic biological processes such as cell adhesion, migration, receptor signaling and cell survival [26, 27]. This evidence concerns the gene ADAM10 and leukemia.