Interestingly, cell cycle, metabolism and apoptotic processes were found to be deregulated by ADAM10 KO in both the transcriptome and proteome in both cell line cells and PDX cells and in both ex vivo and in vivo experimental models, suggesting that the leukemia-promoting function of ADAM10 is, at least in part, independent from the tumor-niche interaction between leukemia cells and the BM. This evidence concerns the gene ADAM10 and leukemia.