For competitive reconstitution in vivo assays, PDX ALL-199 ADAM10 KO cells were reconstituted with either ADAM10-ACT (+ ACT) or ADAM10-ΔMP (+ ∆MP), both linked to T-Sapphire, mixed with iRFP-expressing ADAM10 KO control (CTRL) cells and injected into mice (Fig. 4D). This evidence concerns the gene ADAM10 and acute lymphoblastic leukemia.