CD8A and Autoimmunity: A common feature of OLP is immune infiltration, particularly CD8 + lymphocytes, as well as the expression of Th1 and Th2 cytokines in OLP lesions and tissue secretions [8] The complex cytokine network is thought to play an essential role in the progression and persistence of OLP [9], so there is a speculation on the pathogenesis: infiltrative cytotoxic CD8 + T cells promote apoptosis of oral mucosal basal cells, leading to autoimmunity.