Notably, in patients with AML, malfunction of these process has been linked to alterations in the splicing of several relevant signaling pathways such as FLT3, CD13, cKIT, NOTCH, PI3K or MAPK, which are involved in the regulation of the cell cycle, apoptosis, cellular transformation and splicing [9]. This evidence concerns the gene FLT3 and acute myeloid leukemia.