Both the alpha-thalassemia/mental retardation syndrome X-linked (ATRX) and death-domain-associated protein (DAXX) play a role in chromatin remodeling at telomeres and other genomic sites [99], and the multiple endocrine neoplasia type 1 (MEN1) interacts with DNA damage repair, chromatin remodeling, telomere alteration, and the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/mechanistic target of rapamycin kinase (mTOR) pathway [67]. Here, MTOR is linked to alpha thalassemia spectrum.