Recent study has shown that the number of mutated genes in the PI3K-AKT-mTOR pathway ≥2 was identified as a potential predictor of primary resistance to ICIs in the mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) gastric adenocarcinomas [53]. The gene discussed is AKT1; the disease is gastric adenocarcinoma.