Eleven (GRN, GPNMB, HLA-DQA2, CD63, CD68, EID3, ENTPD1, GAA, LCT, SRI, and TLR3) of the 25 proteins have been reported to be implicated in PD pathogenesis in previous studies (Supplementary Table 3). This evidence concerns the gene TLR3 and Parkinson disease.