Hypoxia-inducible factor-1α (HIF-1α) induces a shift in metabolic pathways to glycolysis by forming a dimer with HIF-1β and binding to intranuclear hypoxia response element (HRE) target genes to induce the expression of GLUT1 and other enzymes in glycolysis [110], playing an important regulatory function in the survival and function of tumor cells and other immune cells [111]. This evidence concerns the gene SLC2A1 and neoplasm.