CD8A and colorectal carcinoma: In colorectal cancer (CRC) cells, the triterpenoid TER of Flavobacterium vulgare mediated glycolytic activity by limiting mTOR activity, increased the expression of multiple metabolic receptors, promoted CD8+ T cell metabolism and activation, while preventing CD8+ T cell dysfunction, reversed the effector dysfunction of CD8+ T cells, secreted more IFN-γ, IL-10, TNF-α, and TGF-β, thereby contributing to enhanced T cell recognition [106].